Probenecid sodium
4-[(Dipropylamino)sulfonyl]benzoic acid sodium salt
CAS: 23795-03-1
Molecular Formula: C13H18NNaO4S
Probenecid sodium - Names and Identifiers
| Name | 4-[(Dipropylamino)sulfonyl]benzoic acid sodium salt |
| Synonyms | Benemid sodium Probenecid sodium sodiuM 4-(dipropylsulfaMoyl)benzoate 4-[(Dipropylamino)sulfonyl]benzoic acid sodium salt |
| CAS | 23795-03-1 |
Probenecid sodium - Physico-chemical Properties
| Molecular Formula | C13H18NNaO4S |
| Molar Mass | 307.341 |
| Boling Point | 438℃ at 760mmHg |
| Storage Condition | Room Temprature |
| Use | Application since Probenecid is almost insoluble in water, it is necessary to convert probenecid into water-soluble salts when combined with penicillin drugs for injection to form a compound injection, and it is usually converted into probenecid sodium which is easily soluble in water. The compound injection of probenecid sodium, probenecid potassium and β-lactam antibiotics and its application can reduce the dosage of β-lactam antibiotics in the compound, so as to effectively reduce the occurrence and development of bacterial resistance caused by ultra high dose of antibiotics; Can also save the resources of antibiotics, reduce the abuse of antibiotics; with the beta-lactam antibiotics including penicillin antibiotics and cephalosporin antibiotics composition powder and freeze-dried powder injection, is with the beta-lactam antibiotics at the same time intravenous injection or intravenous drip. It can effectively prolong the Half-Life (t1/2) of β-lactam antibiotics, increase the area under the curve (AUC), and eliminate the hemolysis of probenecid sodium (potassium), it can protect the safety of probenecid sodium (potassium) in human body, and can be safely and effectively used as a new compound preparation to enter human body through intravenous route. The compound injection composed of β-lactam antibiotics is completely absorbed by the human body because it enters the blood circulation directly, can reach the peak quickly, and has a rapid effect and more remarkable curative effect. |
Probenecid sodium - Preparation technology of probenecid sodium and probenecid potassium
from Palm Bridge research
Application (patent) number:
CN 200410011287
applicant (patent):
Wu Xiaohui
inventor:
Abstract:
The invention relates to a preparation process of probenecid sodium and probenecid potassium, belonging to the field of chemical pharmacy. First (by weight) sodium hydroxide (potassium) dissolved in purified water (or water for injection) all dissolved, then add probenecid, heated to 60±10 ℃, adjust pH to 7.5-10, continue to stir until the pH value is basically constant; Under the condition of 60±10 ℃, filter and sterilize through a filter membrane of 0.45 μm, then carry out fine filtration and pyrogen removal through a filter membrane of 0.22 μm, and dry under aseptic conditions, the raw material of probenecid sodium (potassium), which meets the standard of human medicine injection, is white or white crystalline powder. The preparation process is simple and the use is more convenient. Reduce the occurrence and development of bacterial resistance, save antibiotic resources, convenient for patients, in line with the principles of medical economics.
Last Update：2024-01-02 23:10:35
Probenecid sodium - Compound injection of probenecid sodium and penicillin antibiotics
from Palm Bridge research
Application (patent) number:
CN 200610016603
application date:
Mar 1, 2006
Public/Announcement Number:
CN 1813700 A
applicant (patent):
Wu Xiaohui
inventor:
National and provincial code:
Jilin
cited:
Abstract:
The invention relates to a compound injection of probenecid sodium, probenecid sodium and penicillin antibiotics, and belongs to the field of chemical pharmacy. Penicillin antibiotics including Amoxicillin Sodium and piperacillin sodium, probenecid sodium and Amoxicillin Sodium and piperacillin sodium by conventional process according to 1:3 and 1:5 Mixed compound injection can significantly prolong the plasma elimination half-life (t1/2 β) of Amoxicillin Sodium and piperacillin sodium, and increase the area under the curve (AUC), significantly prolong the compound preparation of Amoxicillin Sodium and piperacillin sodium blood concentration exceeds the corresponding bacterial MIC time (extended T>MIC), significantly reduce the amount of corresponding antibiotics, reduce the number of administration, to avoid the occurrence and development of resistant strains, the preparation is safe, effective, and stable quality.
sovereignty:
1, probenecid sodium and probenecid sodium and penicillin antibiotics composition of compound injection, its special sign is: penicillin antibiotics include Amoxicillin Sodium and piperacillin sodium; The ratio of its compound injection is: Amoxicillin Sodium: probenecid sodium 3:1, (cut-off) piperacillin Sodium: probenecid sodium was 5:1.
Last Update：2023-08-16 22:05:47
Probenecid sodium - Preparation of probenecid sodium and potassium and its compound injection with β-lactam antibiotics and its application
from Baidu Library
patent type:
invention patent
Application (patent) number:
CN200410011287.4
application date:
20041201
Public/Announcement Number:
CN1631876A
Public/announcement date:
20050629
applicant (patent):
Wu Xiaohui
inventor:
National and provincial code:
CN220104
Abstract:
The invention relates to a compound injection preparation of probenecid sodium and potassium and β-lactam antibiotics, and uses thereof, belonging to the field of chemical pharmacy. The sodium salt and potassium salt of probenecid were made into powder injection and freeze-dried powder injection with β-lactam antibiotics, and the β-lactam antibiotics were injected intravenously or drip intravenously at the same time. It can significantly prolong the blood elimination half-life (t) of antibiotics, increase the area under the curve (AUC), the time for the blood concentration of β-lactam antibiotics in the compound preparation to exceed the MIC of the corresponding bacteria was significantly prolonged. To reduce the abuse of antibiotics, to avoid the occurrence and development of resistant strains, the preparation is safe, effective, and stable quality, more convenient to use.
Last Update：2023-08-16 22:05:47
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Product Name: 4-[(Dipropylamino)sulfonyl]benzoic acid sodium salt Request for quotation
CAS: 23795-03-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
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Product List: View Catalog
CAS: 23795-03-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
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Product Name: 4-[(Dipropylamino)sulfonyl]benzoic acid sodium salt Visit Supplier Webpage Request for quotationCAS: 23795-03-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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